Abstract
BackgroundDengue is a major health problem in tropical and subtropical regions. In Colombia, dengue viruses (DENV) cause about 50,000 cases annually, 10% of which involve Dengue Haemorrhagic Fever/Dengue Shock Syndrome. The picture is similar in other surrounding countries in the Americas, with recent outbreaks of severe disease, mostly associated with DENV serotype 3, strains of the Indian genotype, introduced into the Americas in 1994.ResultsThe analysis of the 3'end (224 bp) of the envelope gene from 32 DENV-3 strains recently recovered in Colombia confirms the circulation of the Indian genotype, and surprisingly the co-circulation of an Asian-Pacific genotype only recently described in the Americas.ConclusionThese results have important implications for epidemiology and surveillance of DENV infection in Central and South America. Molecular surveillance of the DENV genotypes infecting humans could be a very valuable tool for controlling/mitigating the impact of the DENV infection.
Highlights
Dengue is a major health problem in tropical and subtropical regions
Phylogenetic reconstruction of dengue viruses (DENV)-3 As shown in the phylogenetic tree (Figure 1), in this study DENV-3 circulation in Colombia was detected since the beginning of 2002
It has been published that DENV-3 has the higher substitution rate between the dengue viruses [21]
Summary
Dengue is a major health problem in tropical and subtropical regions. In Colombia, dengue viruses (DENV) cause about 50,000 cases annually, 10% of which involve Dengue Haemorrhagic Fever/Dengue Shock Syndrome. Dengue viruses (DENV) belong to the genus Flavivirus, transmitted by Aedes mosquitoes and constitutes a major concern in public health, infecting millions of people per year in tropical and subtropical areas throughout the world. DENV causes a wide spectrum of clinical manifestations in humans, ranging from a flu-like illness, known as Dengue Fever (DF), to the more severe Dengue Haemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Studies of evolution and molecular epidemiology of DENV have demonstrated the occurrence of genotype clusters within each serotype [3,4,5,6,7,8,9]. The increase in virus transmission over the last 50 years has possibly increased its adaptive potential, resulting in more virulent genotypes which could be associated with DHF/ DSS [10,11]
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