Simultaneous Characterization of a Mixture of Fluorochemicals Using Three-Dimensional 19F−1H Heteronuclear TOCSY Filtered/Edited NMR Experiments

Abstract

Heteronuclear 19F-1H cross-polarization can be used effectively as a tool for both spectral filtering and editing in the NMR analysis of the increasing number of fluorine-containing compounds encountered in drug discovery. Combined with LC-MS, three-dimensional 19F-1H heteronuclear TOCSY filtered experiments based on this approach have enabled the simultaneous identification of a mixture of closely related dexamethasone derivatives without the need for isolation.