Abstract
FIX inhibitor antibodies (IA) develop in approximately 1-2% of children with severe H B. We have recently seen two unrelated children with HB who developed anaphylaxis or severe anaphylactoid reactions when infused with plasma-derived high purity FIX. In both (ages 9 and 11 months), a FIX IA was first detected at the same time as the first severe allergic reaction.
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