Abstract
The aim of this work was to prepare a non-woven Polypropylene (PP) textile functionalized with bioactive molecules to improve simultaneously its anticoagulation and antibacterial properties. The immobilization of either heparin (anticoagulation agent) or gentamicin (aminoglycoside antibiotic) was already proven to be effective on non-woven PP textiles. This work details how we managed to immobilize both gentamicin and heparin on the textile [1]. The immobilization times were studied in order to determine the best compromise between cytocompatibility, anticoagulant effect and antimicrobial activity.
Highlights
Biomaterials were developed to preserve the integrity and life comfort of patients suffering from intense functional deficiencies or burn/injury victims
We present in this paper our results concerning the immobilization of an anticoagulant molecule and an aminoglycoside antibiotic at the same time on a nonwoven PP surface, for a combined therapeutic activity of the obtained biomaterials
Samples were named PPgAA-EDC-Hx-Gy, with x and y corresponding to the impregnation time in heparin and gentamicin respectively
Summary
Biomaterials were developed to preserve the integrity and life comfort of patients suffering from intense functional deficiencies or burn/injury victims. The aim of this work was to prepare a non-woven Polypropylene (PP) textile functionalized with bioactive molecules to improve simultaneously its anticoagulation and antibacterial properties. The immobilization of either heparin (anticoagulation agent) or gentamicin (aminoglycoside antibiotic) was already proven to be effective on non-woven PP textiles. This work details how we managed to immobilize both gentamicin and heparin on the textile [1].
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