Simultaneous and combinatorial chemical synthesis techniques for the generation and screening of molecular diversity

Abstract

By skilful ‘mixing and sorting’, thousand millions of different compounds, so-called molecular repertoires or molecular libraries, can be produced and screened for biological activity in a very short time. Today, both sophisticated as well as surprisingly simple procedures for simultaneous and combinatorial chemical synthesis open fascinating new perspectives for basic research, biotechnology and drug development. This contribution will give a brief survey of current strategies in the chemical synthesis of oligonucleotide and peptide repertoires with special emphasis on techniques employing membrane-type solid supports developed in this laboratory.