Abstract
Background:LASIK Xtra is a recently described technique which combines LASIK and accelerated corneal cross-linking(CXL) in the same setting. Its long-term outcome in Asians with high myopia is not well described.Objectives:To compare the efficacy, predictability and safety of LASIK Xtra with LASIK in patients with high myopia.Method:This is a retrospective study comparing 50 consecutive eyes undergoing LASIK Xtra for the correction of high myopia and/or myopic astigmatism (-6.63 to -15.50 D manifest spherical equivalent) with a matched control group of 50 eyes undergoing LASIK alone for correction of high myopia (-6.00 to -12.25 D manifest spherical equivalent). Mean follow-up was 5.7 months (range, 1.5-13.3 months) for LASIK Xtra and 3.6 months (range, 1.7-4.2 months) for LASIK only. Outcome measures included Uncorrected Distance Visual Acuity (UDVA), Corrected Distance Visual Acuity (CDVA), refraction and intraoperative and postoperative complications.Results:At post-operative 3 months, all eyes achieved UDVA of 20/40 or better, and 80.0% of LASIK Xtra eyes achieved UDVA of 20/20 or better, compared to 66.0% of LASIK only eyes (p = 0.115). Efficacy indices were 0.99±0.17 for LASIK Xtra and 0.94±0.17 for LASIK only (p = 0.164). The proportion of eyes within ±0.50 D of attempted correction was 84% in the LASIK only group and 72% in the LASIK Xtra group at post-operative 3 months (p = 0.148). Safety indices were 1.11±0.19 and 1.11±0.18 in the LASIK Xtra and LASIK only groups, respectively (p = 0.735).Conclusion:LASIK Xtra achieved comparable safety, predictability and efficacy as LASIK in patients with high myopia. Good refractive stability was attained at 6-12 months. Further long term studies are required to determine whether simultaneous CXL is able to reduce postoperative LASIK keratectasia in high-risk individuals.
Highlights
Laser in situ Keratomileusis (LASIK) is the most commonly performed keratorefractive surgery for the correction of ametropia
Myopia ablation treatment was performed on 50 eyes (100%) and 25 eyes (50%) with the Wavelight EX500 (Alcon Laboratories, Fort Worth, TX) for LASIK Xtra and LASIK only groups, respectively
Long-term studies evaluating the use of CXL to treat keratoconus have shown that it can stabilize keratoconic corneas for more than 3 years. [17, 18] we are unaware of any study in literature reporting long term outcomes of LASIK Xtra in Asians with high myopia, one may anticipate that CXL in a non-diseased eye would result in similar stabilization
Summary
Laser in situ Keratomileusis (LASIK) is the most commonly performed keratorefractive surgery for the correction of ametropia. It results in faster visual recovery and causes less discomfort compared to surface ablation techniques. Crosslinking causes photopolymerization of corneal stromal fibers by the combined action of a photosensitizing substance (riboflavin) and Ultraviolet-A (UVA) light. This results in formation of new intrafibrillar and interfibrillar covalent bonds among stromal collagen fibers, which increases the rigidity of the corneal collagen and its resistance to deformation [10]. LASIK Xtra is a recently described technique which combines LASIK and accelerated corneal cross-linking(CXL) in the same setting. Its long-term outcome in Asians with high myopia is not well described
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
