Abstract
Simulated moving bed chromatography process, which is a multicolumn chromatography process, has been used in various industrial applications. Dynamic axial compression columns are key elements in simulated moving beds, and their flow characteristics are worth exploring using state-of-the-art numerical methodologies. In this study, new fluid distributors for the dynamic axial compression column were designed and fabricated based on mass conservation in fluid mechanics and the computer-aided design in the preliminary stage. Computational fluid dynamics was employed to resolve the flow field, and the numerical chromatograms were validated by laboratory experiments. For the computational fluid dynamics–based simulation of flow in the dynamic axial compression, the transient laminar flow fields were described by the momentum and species transport equations with Darcy’s law to model the porous zone in the packed bed. In addition, reverse engineering processes were applied to obtain the unknown physical parameters, such as viscous resistance and adsorption equilibrium coefficients. Moreover, including the adsorption equilibrium equation in the fundamental governing equations made the simulated results agree with the experimental data in chromatograms, providing a more feasible result for practical applications.
Highlights
The simulated moving bed (SMB) technique is considered a multicolumn chromatography process
The dynamic axial compression (DAC) column is the key element in the SMB
The results show that computational fluid dynamics (CFD) combined with computer-aided design (CAD) solid modeling is a good approach to explore detailed flow fields in DAC columns, and it is an effective method for parameter analysis in innovative distributor design
Summary
The simulated moving bed (SMB) technique is considered a multicolumn chromatography process. It has been applied in various industrial fields, such as foods, petrochemicals, fine chemicals, and pharmaceuticals.[1] In the SMB process, periodically shifting the inlet and outlet nodes simulates the counter current movement of the adsorbent bed to the direction of the flow for certain time intervals. The dynamic axial compression (DAC) column is the key element in the SMB. In this column, different solutes can be separated from the solvent due to their different flow characteristics in packed beds. The SMB process can achieve low solvent consumption and high
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