Abstract
Scanning acoustic microscopy (SAM) is one of the most powerful techniques for nondestructive evaluation and it is a promising tool to characterize the elastic properties of biological tissues/cells. Exploring a single cell is important since there is a connection between single cell biomechanics and human cancer. SAM provides advantages for investigating cells in the fact that it is non‐invasive, provides elastic properties information in sub‐cellular details, and no chemical stain on the cells. The first goal of this research is to develop a program for simulating the images and contrast mechanism obtained by high‐frequency SAM. We focus on the mechanical and acoustical properties of HeLa cells, which can be analyzed from the V(z) response. Two new algorithms for simulating V(z) responses involve calculation of reflectance function for coupling medium/cell/substrate system, and are constructed based on ray theory and wave theory (angular spectrum). The second goal is to design/optimize transducer arrays for SAM. One‐dimensional and two‐dimensional (2‐D) linear array and phased arrays are simulated using FIELD II program to analyze image resolution and volumetric imaging capabilities. The new 2‐D array design will enhance the performance of SAM by electronically scanning and by providing a four‐dimensional image of the cells development phase.
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