Abstract
We performed computer simulations to improve transmission efficiencies of a dual ion funnel system implemented onan FT-ICR MS. We found that the low m/z range from 50 to 150 could be significantly improved by operating the two ion funnelsat different RF amplitudes. These new operational conditions could be applied to analyze metabolome samples, whichrequire high sensitivity in the m/z range from 50 to 1,000.
Highlights
The novel ion funnel interface was implemented in 1997 to improve ion transmission at the first vacuum stage of atmospheric pressure ionization mass spectrometry (API-MS) with differential vacuum stages.[1]
We found that the ion transmission efficiency is determined in the exit region of the quadrupolar ion funnel
Transmittance of ions through an ion funnel at a given background pressure depends on their mass at specific RF amplitudes
Summary
The novel ion funnel interface was implemented in 1997 to improve ion transmission at the first vacuum stage of atmospheric pressure ionization mass spectrometry (API-MS) with differential vacuum stages.[1]. Using 1,000 singly charged ions with the same selected mass in the first funnel, ion trajectories were calculated for the second funnel, and the total transmission efficiency of the dual ion funnel system was calculated based on the results of simulations from each funnel. Trajectories were similar even for ions of different masses in the first funnel region (Figure 3).
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