Abstract
In this study, a highly angular sensitive surface plasmon resonance (SPR) biosensor has been designed for cancer cell detection. The proposed surface plasmon resonance biosensor structure is based on Kretschmann configuration, which works on an angular interrogation technique. The proposed SPR biosensor has enormous possibility to detect the various kind of cancer cells. The refractive index alteration of different cancerous (skin, cervical and blood) cells is 1.360–1.390. The proposed SPR biosensor is stacked with multilayers having CaF2 prism, silver metal, bismuth telluride (Bi2Te3) and MXene (Ti3C2Tx) layers. The performance parameters like angular sensitivity, quality factor, detection accuracy, and electric field intensity distribution have been optimized in this article. Here, various kind of cancer cells (skin, cervical and blood) have been also analyzed and corresponding angular sensitives are 252.20, 305.70 and 319.46 deg R−1IU−1 respectively. The proposed SPR biosensor shows best results for blood cancer cell detection. Some other important performance parameters like detection accuracy, quality factor, and electric field intensity distribution have also been calculated for proposed SPR biosensor device. The simulation results have been performed by MATLAB 2019a software. The proposed SPR biosensor design may open a new way for the medical industry.
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