Abstract
BackgroundMagnetic nanoparticles (MNPs) have been proposed as drug carriers for targeted therapy. Noninvasive imaging methods that can compute the distribution of MNPs have also attracted much attention. Method: Based on the Langevin theory, the theoretical relationship between the magnetic force and the concentration of MNPs was derived. The acoustic pressure wave equation containing the concentration of MNPs was established. Result: The acoustic pressure waveform reflected the dimension and position of the MNPs region. From reconstructed images, MNPs regions with different concentrations and different sizes were clearly distinguished. Conclusion: The concentration of MNPs can be parsed from the acoustic signals generated by particles vibrations. This conclusion indicates that magneto-acoustic concentration tomography of magnetic nanoparticles with magnetic induction (MACT-MI) has potential to detect and reconstruct the concentration of MNPs in biological tissue.
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