Simulation-Omitted Replan with Cone Beam Computed Tomography based Adaptive Online Radiotherapy System ― Transferring Adapted Plan to Non-Adaptive Ring Gantry Linear Accelerator for Image Guided Radiotherapy

Abstract

Artificial intelligence powered cone beam computed tomography (CBCT) based online adaptive radiotherapy (oART) system offers a streamlined and efficient process for daily ART as the default. In our prior work, we developed a workflow to utilize this oART system as simulation-omitted replan platform and treat the adapted plan on the oART system with image guided radiotherapy (IGRT) until next adaptation. However, the IGRT fractions will occupy the treatment slots of the machine. In this work, we aim to develop a semi-automatic workflow to allow the adapted plan to be treat on the non-adaptive ring gantry linear accelerator (non-ART Linac) and dedicate the oART system for adaptive treatments. The oART system and the non-ART Linac were machine-matched to the same representative beam data. In the oART system, the initial plan is setup as 'adaptive' treatment and patients are only treated on the oART system for adaptive replan. The IGRT fractions are all treated on the non-ART Linac. An API script was developed to automatically (1) grab the adapted DICOM plan files from the secondary calculation system and write directly back to the database of the treatment management system (TMS), (2) change the DICOM tags to make the files compatible in the TMS system, (3) insert the kV-CBCT field to make the plan deliverable in the non-ART Linac. There are minimum remaining manual steps to setup the number of fractions to the intended number of IGRT fractions and to link plan to the prescription in TMS. We compare the required resources and the percentage of ART treatments on the oART system before and after the implementation of the proposed workflow to quantify the improvement of service. The proposed workflow and automation eliminated the need to convert between IGRT/ART fractions in the Ethos system and reduced manual work by 25 minutes each adapted plan transfer. Table 1 summarizes the number of physics tasks and the percentage of ART fractions in oART system per month before and after the proposed workflow. This workflow reduced the physics IGRT/ART tasks from 107±31 to 65±21 tasks per month (p<0.05). Percentage of ART treatments on oART system increase from 30%±3% to 57%±13% (p<0.05). We also observed increased utilization of ART from 46% in the 1st month to 71% in the 6th month since it is easier to find a feasible time slot for the clinical team. The majority of the remaining IGRT on oART system are lung SBRT where the first fraction is not adapted due to being within a week of the simulation. Leveraging CBCT based ART system as replan platform and non-ART Linac as IGRT platform is clinically feasible. This process significantly improved the turnaround time for replan, reduced the required resource and promotes the utilization of oART.