Abstract
A dialysis method that allows the effect of viscosity on the gastrointestinal transit rate to be simulated in vitro is described. The method has been applied to a series of aspirin suspensions. Various suspending agents have been used to produce suspension media with a range of viscosities. The results correlated with previously obtained bioavailability parameters and support the suggestion that the effect of viscosity on gastrointestinal transit rate is an important factor in determining the bioavailability of aspirin from such formulations when administered to the rabbit.
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