Simulation of Gold Nanoparticle Transport during MHD Electroosmotic Flow in a Peristaltic Micro-Channel for Biomedical Treatment.

Muneerah Al Nuwairan,Basma Souayeh

doi:10.3390/mi13030374

Abstract

The study of gold nanoparticles (AuNPs) in the blood flow has emerged as an area of interest for numerous researchers, due to its many biomedical applications, such as cancer radiotherapy, DNA and antigens, drug and gene delivery, in vitro evaluation, optical bioimaging, radio sensitization and laser phototherapy of cancer cells and tumors. Gold nanoparticles can be amalgamated in various shapes and sizes. Due to this reason, gold nanoparticles can be diffused efficiently, target the diseased cells and destroy them. The current work studies the effect of gold nanoparticles of different shapes on the electro-magneto-hydrodynamic (EMHD) peristaltic propulsion of blood in a micro-channel under various effects, such as activation energy, bioconvection, radiation and gyrotactic microorganisms. Four kinds of nanoparticle shapes, namely bricks, cylinders and platelets, are considered. The governing equations are simplified under the approximations of low Reynolds number (LRN), long wavelength (LWL) and Debye–Hückel linearization (DHL). The numerical solutions for the non-dimensional equations are solved using the computational software MATLAB with the help of the bvp4c function. The influences of different physical parameters on the flow and thermal characteristics are computed through pictorial interpretations.

Highlights

Gold nanoparticles have been greatly used for diagnostics of disease, therapeutics [5], tumor necrosis factor, transmission electron microscopy, scanning electron microscopy, polyethylenglycol and plasmonic photothermal therapy [6]
In the presence of a magnetic field, a force called the Lorentz force arises in the flow domain and it leads to a reduction in the fluid flow rate
The influence of activation energy and bioconvection on the propulsion of gold–blood nanofluid is considered in an asymmetric peristaltic channel

Summary

Introduction

Metallic nanoparticles have been used widely in biomedical treatments and, among them, AuNPs attract extreme attention, due to their inherent characteristics, such as surface plasmon resonance (SPR), and their physicochemical, electronic and optical fields, which can be modified by converting the particle characterizations, such as environment, aspect ratio, size and shape. This leads to the provision of extreme functionalization properties, of use in many applications in diverse categories of biomedicine, for instance, in imaging, targeted drug delivery, sensing, bioimaging, photodynamic and photothermal therapy.

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