Abstract
The subject of analysis in this study is a human brain exhibiting edema. The cells of an edematous brain contain an overabundance of cerebrospinal fluid (CSF). Brain edema appears as a white region in magnetic resonance images of the brain. However, such images show only that an excess of CSF is present in the cells ; they give us no information on the direction or quantity of CSF flux. Therefore, we studied the flow of CSF in brain through computer simulation. First, we constructed a two-dimensional model of a brain using FEM based on Poisson's equation and a diffusion equation and simulated the CSF flow in the brain tissue in order to determine the quantity of CSF present. Second, we simulated a case in which colored-albumin is poured into the brain tissue at the site of edema and compared the distribution of CSF in this case with that in a CT image which exhibits edema. The results on CSF flow obtained in the simulation are similar to those obtained by pathological observation. Moreover, we believe that these simulations help us to develop new medical treatments for brain disease such as edema.
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