Abstract
Single grained high temperature superconductor (HTS) bulks can trap a magnetic field up to approximately 17 tesla at low temperatures, which is significantly larger than that of permanent magnets (PMs) at about 0.5–1.0 tesla. This study compared the trajectory of magnetic particles using three different magnetic field sources, i.e., an HTS bulk working at 65K and 77 K and a PM, respectively. In addition, the theoretical trajectory of magnetic particles was also calculated and compared with that of the direct experimental observations, which indicated high calculation accuracy. Due to the magnetic flux density gradient differences between a PM and HTS bulk, the distributions of the magnetic particles were also different, which showed the highest density at the edge for a PM and at the center for an HTS bulk. In this report, it was shown that the HTS bulk working at 65 K resulted in a higher magnetic force that can concentrate more magnetic particles in a small area.
Highlights
Magnetic drug delivery systems (MDDS) comprise a type of therapeutic process developed in 1980 [1], that can be applied in cancer and gene therapies
It was found that using permanent magnets (PMs) as a magnetic field source led to the capture of all the iron particles, but high temperature superconductor (HTS) only captured iron particles when y was smaller than 18 mm
This study showed that the calculated trajectories concurred with the experiment results for both PM and HTS magnets, respectively
Summary
Magnetic drug delivery systems (MDDS) comprise a type of therapeutic process developed in 1980 [1], that can be applied in cancer and gene therapies Some magnetic materials such as Fe3O4 are attached to the drugs, and the drugs are manipulated by an external magnetic field source to move to the affected area (target area). Some studies have used the HTS bulk as the magnetic field source in MDDS applications, displayed good magnetic drug delivery results[13]-[15]. To determine the effects of the magnetic field and field gradient, we used a permanent magnet (PM) and homemade high temperature superconductor bulk (HTS) [21], [22] as the magnetic source and compared our results with the simulation results
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