Abstract
Simulation and mathematical modeling have proven useful in evaluating diverse physiological and biochemical systems. However, simulation methods have had extremely limited application in the formulation and evaluation of models of the blood coagulation system. The utility of this tool is illustrated via a mathematical model of the interactions of thrombin with fibrinogen, antithrombin III, and heparin-antithrombin III complex. This model provides exemplary simulations consistent with several empirical characteristics of the anticoagulant effect of heparin. Simulation methods provide a powerful tool with which to characterize the dynamic nature of the hemostatic process and its responsiveness to endogenous perturbations or pharmacological interventions.
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