Abstract
We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). The OCT output signal is created using two different simulations for the reference and sample arms, with a successive computation of the interference signal with external software. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work aims to understand to what extent time domain OCT can be used for non-invasive, direct optical monitoring of peripheral nerve activity.
Highlights
Optical coherence tomography is a low coherence interferometric technique that has been first used in 1991 to examine the peripapillary region of the retina [1] and has, since played a very important role in medical imaging
There are different techniques available to simulate a process like optical coherence tomography (OCT), e.g. Monte Carlo [2, 3] or computational electrodynamics techniques
Examples of computational electrodynamics techniques are the method of moments and the finite element method in the frequency domain and the finite-difference time-domain (FDTD) method in the time domain
Summary
Optical coherence tomography is a low coherence interferometric technique that has been first used in 1991 to examine the peripapillary region of the retina [1] and has, since played a very important role in medical imaging. There are different techniques available to simulate a process like OCT, e.g. Monte Carlo [2, 3] or computational electrodynamics techniques. Examples of computational electrodynamics techniques are the method of moments and the finite element method in the frequency domain and the finite-difference time-domain (FDTD) method in the time domain. We have decided to use the FDTD method as its time domain nature allows to obtain results for a range of frequencies using a single simulation. This allows to simulate the low coherence gate property of OCT by using, as the light source, a pulse which length in time is chosen to match the desired width of the frequency spectrum
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