Abstract
IntroductionThe NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.MethodsFor 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs).ResultsCorrelations with the original ppIF-derived 90-min VTs increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived VTs (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived VTs (ρ = 0.97–1.00), which suffered regionally variant negative bias.ConclusionsWhere arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
Highlights
The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions
Quantification of [18F]GE-179 volume of distribution (VT) was based on 90-min scans and compartmental modelling within regions of interest (ROIs) and using rank-shaping regularisation of spectral analysis (SA) at the voxel level. [18F]GE-179 binding in rats and non-human primates could not be blocked in one recent study [4], but interpretation is complicated by the use of anaesthesia with the NMDA receptor inhibitors isoflurane [5] ± ketamine
We report our investigations into (1) whether arterial blood sampling is avoidable, via the use of standardised uptake values (SUVs) or population-based input functions (PBIFs) and (2) whether shorter scans are feasible
Summary
The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. We reported the first-in-human use of the NMDA receptor-selective PET radiotracer, [18F]GE-179 [2], an analogue of the non-competitive antagonist, [11C]CNS-5161 [3]. Quantification of [18F]GE-179 volume of distribution (VT) was based on 90-min scans and compartmental modelling within regions of interest (ROIs) and using rank-shaping regularisation of spectral analysis (SA) at the voxel level. Wide utilisation of [18F]GE-179 is limited by the need for arterial blood sampling and 90-min scans. We report our investigations into (1) whether arterial blood sampling is avoidable, via the use of standardised uptake values (SUVs) or population-based input functions (PBIFs) and (2) whether shorter scans are feasible
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