Abstract
Abiraterone acetate is an orally administered selective androgen biosynthesis inhibitor It is an irreversible inhibitor of cytochrome CYP17AThis enzyme is expressed in testicular, adrenal, and prostatic tumour tissues and is required for androgen biosynthesis.Abiraterone is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body.A Novel, simple, accurate, precise and reproducible UV spectrophotometric method has been developed and validated for estimation of Abiraterone acetate bulk and its formulations. After determining the solubility we had selected methanol as a solvent and Abiraterone acetate has absorbance at the wavelength of maximum ?max254nm. The drug was characterized by the melting point test. Proposed method was precise with RSD less than 2%. linearity test was approved within the range of 10-60µg/ml for with the correlation coefficient (R2) of 0.9991. Accuracy was 100.03%. LOD and LOQ were 0.006µg/ml and 0.018µg/ml respectively. The spike recovery of Abiraterone acetate in tablet was 99.88%.
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