Abstract
A simple and rapid method has been developed for the isolation of thermally labile DNA alkylation products. Use of calf thymus DNA in combination with size exclusion filtration provides good yields >40% of chlorambucil-guanine adducts. Application of this method to the isolation of alkylation products of carzinophilin/azinomycin B affords material consistent with guanine monoalkylation.
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