Simplified Method for Renal Uptake Rate Measurement with 99mTc-Dimercaptosuccinic Acid Using Graphical Analysis.

Abstract

In our previous paper, we demonstrated a new method for renal uptake rate measurement with 99mTc-dimercaptosuccinic acid (DMSA) which required no background and kidney depth corrections and only 20 min for examination. In this study, we developed a simple and practical alternative approach using graphical analysis. The net uptake rate of DMSA by tubular cells (K) calculated using graphical analysis correlated well with the renal uptake rates measured two hours after DMSA administration (r=0.918 for the 3-parameter model and r=0.924 for the 4-parameter model), and agreed well with the K values obtained using the previous method (r=0.997 for the 3-parameter model and r=0.998 for the 4-parameter model) . These results indicate that the present method can be an alternative approach to our previous method. We believe that this method will facilitate even more widespread utilization of the quantitative assessment of DMSA uptake by planar scintigraphy, because it is much simpler for practical use as compared to the previous method.