Simple to Complex Amide Derivatives as Potent Anti‐Tuberculosis Agents: A Literature Survey of the Past Decade

Abstract

AbstractTuberculosis (TB) is a life‐threatening persistent transmittable disease caused by Mycobacterium tuberculosis (MTB) still leftovers one of the most widespread, contagious, and leading deadliest diseases known to mankind all over the world. In recent years, numerous efforts have been made to subjugate the treatment outcomes, and to conquer the drug‐resistant TB (DR‐TB), multidrug‐resistant TB (MDR‐TB), extensively drug‐resistant TB (XDR‐TB), and totally drug‐resistant TB (TDR‐TB) phenomenon. In quest of searching for novel anti‐TB agents, several derivatives containing amide functionality have been synthesized and tested for their anti‐TB activity. It having found that drugs or lead compounds contain amide functionality are privileged motifs that act as primary pharmacophores in many bioactive compounds and possess various biological activities including anti‐tubercular, anti‐inflammatory, anti‐HIV, anti‐malarial, anti‐convulsant, anti‐hypertensive, anti‐diabetic, anti‐depressant, analgesics anti‐cancer, anti‐fungal, anti‐oxidant, anti‐microbial and so on. This review covers the past decade (2010–2022) of advances made towards the breakthrough of anti‐TB agents holding amide functionality. It is hoped that the comprehensive literature survey will be helpful and will open a new avenue in the pursuit for rational designs of more active and less toxic amide functionality‐based anti‐TB drugs.