Abstract
Treatment of 2′,3′,5′-tri-O-acetyl-5-iodouridine and 3′,5′-di-O-acetyl-5-iododeoxyuridine with trifluoromethyl iodide and copper powder gave the corresponding 5-trifluoromethyluridine derivatives; this is the first example of direct trifluoromethylation of nucleosides.
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More From: Journal of the Chemical Society, Chemical Communications
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