Simple Synthesis of 2-Amino-N'-(9H-Fluoren-9-Ylidene)-Hexahydroquinoline-3-Carbohydrazide Derivatives

Abstract

This work represents a simple and efficient synthesis of novel 2-amino-N'-(9H-fluoren-9-ylidene)-hexahydroquinoline-3-carbohydrazide derivatives via the multi-component reaction of diverse anilines, dimedone, 9-fluorenone, cyanoacetohydrazide, and aromatic aldehydes in the presence of piperidine as a catalyst. The proposed approach has some advantages as good yields, green medium, short reaction times, simple work-up, and purification process with no chromatographic technique compared with other methods. Supplemental data for this article is available online at at the publisher’s website.