Abstract
Two simple, precise and accurate visible spectrophotometric methods were developed for the estimation of Aceclofenac in bulk drug and in pharmaceutical formulations. The proposed methods were indirect and based on determination of aceclofenac after its reaction with either (p-dimethylaminocinnamaldehyde (PDAC) or 3-Methyl-2- benzothiazolinone hydrazine hydrochloride (MBTH) and measuring the chromogen at the λmax by 658 and 592, respectively. Beers law obeyed in the concentration range of 1–200μg/ml for method A and 1–100μg/ml for method B. The accuracy of the methods was determined by recovery studies. The methods showed good reproducibility and recovery with relative standard deviation (RSD) (in %) less than 2. The methods were found to be simple, economical, accurate and reproducible and can be used for routine analysis of Aceclofenac in bulk drug and in pharmaceutical formulations.
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