Abstract
A simple method for the differentiation of three cathinone-type regioisomers, 2-, 3- and 4-methyl-α-pyrrolidinobutiophenone (MePBPs), using a bromination procedure was developed in this study. The bromination was performed in a vial where isomers of MePBP, iron(III) bromide, and liquid bromine were added. After excess bromine in the vial was evacuated and an alkaline solution was added, the compounds were extracted with n-hexane and analyzed by gas chromatography–mass spectrometry. This method is a useful way to differentiate among isomers of MePBPs using the differences in the number of peaks generated and the intensity ratio between peaks on the extracted ion chromatograms. This method seems to have great potential to be applied to regioisomer differentiation of other drugs.
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