Abstract
We have developed three methods for removing organic impurities as well as a solid-phase extraction (SPE) method for removing metallic and ionic impurities from recovered [ 18O]H 2O. Preliminary experiments with [ 16O]H 2O were used to determine the optimal purification conditions. These showed that UV irradiation rapidly (<4 h) eliminated low boiling point impurities such as acetonitrile and acetone with only a slight loss of mass. A combination of UV irradiation and purging with ozone removed high boiling point impurities such as ethanol and methanol more quickly than UV irradiation alone. UV irradiation followed by a SPE with [ 18O]H 2O removed all organic and inorganic impurities. The purified [ 18O]H 2O gave a saturation yield of 128.62±15.6 mCi/μA for [ 18F]fluoride and a 49.8±12.7% radiochemical yield for [ 18F]fluorodeoxyglucose.
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