Abstract

Objective: Peptic ulcer disease in children is rare. Therefore, the diagnosis can be missed until complications such as perforation or hemorrhage occur. Few reports have investigated the procedures and outcomes of children who have undergone operations for perforated duodenal ulcers. We report our experience with the modified Graham technique for perforated duodenal ulcers in nine children and review the literature. Methods : The records of patients operated on for a perforated duodenal ulcer in the last 8 years in two pediatric surgery centers were evaluated retrospectively. Patient demographics, symptoms, time to admission to hospital, operative findings, and postoperative clinical course were evaluated. Results : Nine children (mean age 13.2 years, range 6–170 years) were included. All patients were admitted in the first six hours after their abdominal pain started. In three patients, there was free air on plain x-rays, while the x-rays were normal in six. All perforations were located on the anterior surface of the first part of the duodenum and repaired with primary suturing and Graham patch omentoplasty. The recovery was uneventful in all patients. In five patients, urea breath tests were performed postoperatively for Helicobacter Pylori, and the results were positive. All patients underwent triple therapy with lansoprazole, amoxicillin, and clarithromycin. The mean follow-up time was 58 (range 3–94) months. Conclusions : Peptic ulcer perforation should be suspected in children who have acute abdominal pain and peritoneal signs, especially when their suffering is intense. The simple patch repair and postoperative triple therapy for Helicobacter Pylori are safe and satisfactory for treating peptic ulcer perforation in children.

Highlights

  • Histamine-2 receptor blockers, proton pump inhibitors and treatment of Helicobacter pylori have already replaced the role of elective surgery in peptic ulcer disease (PUD).[1]

  • This study reports our experience with the Graham patch repair for perforated duodenal ulcers in nine children and reviews the literature

  • Primer PUD is not associated with another disease but most cases of primary peptic ulcers are associated with H. pylori infection

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Summary

Introduction

Histamine-2 receptor blockers, proton pump inhibitors and treatment of Helicobacter pylori have already replaced the role of elective surgery in peptic ulcer disease (PUD).[1] Current treatment modality has decreased the rate of elective surgery, but emergent surgical conditions such as peptic ulcer perforation ( PUP ), bleeding or obstruction have not been decreased.[2] effects of improvement in the management in children are not apparent as in adults because the literature on the subject is uncommon. Omental patch (Graham patch) closure of perforated duodenal ulcers was first described in 1929 by Cellen-Jones and later by Graham in 1937.3. Most of the literature on PUP is on adults; PUP has been investigated less frequently in children.[3] This study reports our experience with the Graham patch repair for perforated duodenal ulcers in nine children and reviews the literature

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