Abstract
The same mutations that expand the host range of a particular retrovirus also enhance its capacity to kill the cells that it ordinarily infects—altogether, not such a good strategy for spreading itself, according to John M. Coffin of Tufts University Medical School in Boston, Mass., and G. Jonah A. Rainey, now at the Salk Institute, La Jolla, Calif. “In other words, the ability to infect many hosts comes at a … price” in terms of overall success for this pathogen, Rainey says, explaining findings that the researchers published in the January 2006 Journal of Virology (80:562–570).
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