Abstract
3-(Pyrrolidin-1-yl)piperidine (1) is a conformationally rigid diamine having major importance in medicinal chemistry [1-4]. The currently known method for the synthesis of this compound is of little use for the production of large quantities, being a complex, six-stage modification of 3-hydroxypiperidine [3, 4]. We propose a novel method for the synthesis of compound 1 based on the exhaustive catalytic hydrogenation of the pyrrolylpyridine 2 [5] which, in turn, can readily be prepared by the condensation of 3-aminopyridine 3 with 2,5-dimethoxytetrahydrofuran.
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