Abstract
Antiatherogenic Effect of Almond Oil in Streptozotocin Induced Diabetic RatsMona Anwar, Wafaa Ghoneim Shousha, Hatem A. El-mezayen, Raafat A wadallah, Maha El-Wassef, Naglaa M. Nazif and Mona A. El-bana
Highlights
Nitric oxide (NO) is considered the most important signaling molecule in the vasculature
In comparison to control group, atorvastatin showed a significant increase in endothelial nitric oxide synthase (eNOS) (48.16% for vanadium, and 44.3% for nitrate reductase, P
The mean changes of endothelial nitric oxide synthase activity before and after six weeks of treatment course were listed in Table (2) and Figure (1)
Summary
Nitric oxide (NO) is considered the most important signaling molecule in the vasculature. Nitric oxide is produced by a group of enzymes called nitric oxide synthases (NOS). These enzymes catalyze the production of NO and L-citrulline from L-arginine, O2, and NADPH derived electrons (Moncada and Higgs, 2006). Mammalian systems contain three isoforms of the enzyme: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). Endothelial NOS is the major source of the bioavailable NO in the vasculature (Knowles and monkanda, 1994). Endothelial nitric oxide synthase plays a role in the control of vascular tone, insulin secretion, and in the regulation of cardiac function and angiogenesis
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