Abstract
The COVID-19 infection, caused by SARS-CoV-2, is inequitably distributed and more lethal among populations with lower socioeconomic status. Direct contact with contaminated surfaces has been among the virus sources, as it remains infective up to days. Several disinfectants have been shown to inactivate SARS-CoV-2, but they rapidly evaporate, are flammable or toxic and may be scarce or inexistent for vulnerable populations. Therefore, we are proposing simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus efficacy of the proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 103.7 to 106.7 EID50), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19.
Highlights
The World Health Organization (WHO) has declared that COVID-19 is a pandemic, caused by the new human coronavirus (SARS-CoV-2) that has already infected more than 20 million people and cause more than 700 thousand deaths worldwide by August 2020 [1]
The film for hand application was prepared using detergent and soybean oil (20:1 ratio), and the mixture was completely homogenized until a white emulsion was obtained
The 1 H NMR spectra of the film extracts showed that the major components of the detergent were sodium dodecyl sulfate (SDS) and linear alkylbenzene sulfonates (LAS)
Summary
The World Health Organization (WHO) has declared that COVID-19 is a pandemic, caused by the new human coronavirus (SARS-CoV-2) that has already infected more than 20 million people and cause more than 700 thousand deaths worldwide by August 2020 [1]. The efficiency of surface disinfectant has been investigated and it has been shown to inactivate SARS-CoV-2 in a few minutes [3,4]. These virus inactivation agents rapidly evaporate, are flammable, become inefficient soon after application and, the sanitized. Res. Public Health 2020, 17, 6456; doi:10.3390/ijerph17186456 www.mdpi.com/journal/ijerph
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