Abstract
An assay method for the determination of acyclovir from pharmaceutical preparations has been developed for assessment of product quality utilising high-performance liquid chromatography. The chromatographic conditions comprised a reversed-phase C 18 column (250×4.6 mm i.d.) with a mobile phase of acetonitrile-20 mmol l −1 aqueous ammonium acetate buffer of pH 4.5 (40:60). The flow rate was 0.8 ml min −1 and UV detection was used at 250 nm. Calibration graph was linear in the range 1.98–59.4 μg ml −1. The method has been validated according to current guidelines including assay of pharmacopoeial standard tablets. Recoveries ranged from 96.64 to 99.53%. The exipients present in the tablets did not interfere with the method.
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