Abstract
The batch and continuous flow processes for the synthesis of 2-(3-indolyl)-1,4-naphthoquinone catalyzed by trifluoroacetic acid are reported. Continuous flow synthesis shows more efficient than batch synthesis. The flow system was easily assembled from commercially available tubing, a simple 3-way connector, and a set of peristaltic pumps. Using this system, a range of indoles and 1,4-naphthoquinone could be smoothly transformed under mild reaction conditions to the desired 2-(3-indolyl)-1,4-naphthoquinones in good to excellent yields and in short reaction times. Using the reactor greatly improved safety and additionally facilitated easy scaled up of the reaction.
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