Abstract
The previously reported preparation of O-[ 11C]methyl- l-tyrosine ([ 11C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [ 11C]methyl iodide ([ 11C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [ 11C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [ 11C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.
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