Simple and mild esterification of N-protected amino acids with nearly equimolar amounts of alcohols using 1- tert-butoxy-2- tert-butoxycarbonyl-1,2-dihydroisoquinoline

Abstract

A very mild, one-step esterification using nearly equimolar amounts of N-protected amino acids and alcohols, in conjunction with 1- tert-butoxy-2- tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) as a novel condensing reagent is described.