Simple and efficient synthesis of 2,6-dialkyl-3,5-dialkoxycarbonyl-4-(3-aryl-1-phenyl-pyrazol-4-yl)pyridines using TPAP/NMO as a catalyst under mild conditions

R Murugan,K Ramamoorthy,S Sundarrajan,S Ramakrishna

doi:10.1016/j.tet.2011.02.040

Simple and efficient synthesis of 2,6-dialkyl-3,5-dialkoxycarbonyl-4-(3-aryl-1-phenyl-pyrazol-4-yl)pyridines using TPAP/NMO as a catalyst under mild conditions

R Murugan, K Ramamoorthy + Show 2 more

https://doi.org/10.1016/j.tet.2011.02.040

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Journal: Tetrahedron	Publication Date: Feb 19, 2011
Citations: 11

Affiliation: National University of Singapore, Institute of Materials Research and Engineering, King Saud University

#Tetrapropylammonium Perruthenate #Mild Conditions + Show 3 more

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Abstract

Biologically important pyrazolylpyridines were synthesized in excellent yield by the oxidation of pyrazolyl 1,4-dihydropyridines (pyrazolyl 1,4-DHPs) using tetrapropylammonium perruthenate/ N-methylmorpholine- N-oxide (TPAP/NMO) under mild conditions at 0 °C.

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