Abstract
Ciprofloxacin is a synthetic chemotherapeutic agent used in the treatment of infections caused by gram negative and gram positive bacteria. Due to its versatility in anti-bacterial chemotherapy, this study sets out toprovide simple, in-expensive and sensitive analytical techniques involving UV-spectrophotometric and titrimetric methods. Method validation was by means of a precision assay. The methods were applied to thedetermination of ciprofloxacin hydrochloride in tablets available within the Nigerian drug distribution system. Ten different brands of ciprofloxacin tablets were analysed for ciprofloxacin by UV spectrophotometry at theëmax of 271.5 nm and redox titration using KMnO4 in alkaline medium. The spectrophotometric results, expressed as a percentage of stated amounts of ciprofloxacin were 95.5 - 103.5%w/w, while the titrimetric results were 95.0 - 100.3%w/w. Some 70% of the results from the two methods were in line with the high performance liquid chromatographic method specified by BP 2008. The results show that both the spectrophotometric and titrimetric methods described are suitable for the assay of ciprofloxacin in tablets.
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