Abstract
Non-thermal atmospheric pressure is applied in various medical fields such as wound healing, blood coagulation, and cancer treatments [1-4]. We have previously developed non-thermal atmospheric pressure plasma with high electron density, and applied for cancer treatment. We found that medium exposed to plasma, what we call “plasma-activated medium (PAM)” exhibited anti-tumor effects on glioblastoma cells. Based on western blotting analyses, we constructed a model that PAM induced apoptosis on glioblastomas by inhibiting the survival and proliferation signaling network. We have also developed, what we call “plasma-activated Ringer’s lactate solution (PAL)”, for clinical applications and we found that plasma-activated lactate is a factor which exhibits anti-tumor effect on glioblastomas [5]. Both PAM and PAL exhibited anti-tumor effects on glioblastoma cells. However, the sensitivities to PAM and PAL were different. Glioblastoma cells were generally more sensitive to PAL than PAM. The sensitivities of cells to plasma-activated solutions are thought to be determined by sum effects of factors which positively and negatively exhibit anti-tumor effects. PAL contains plasma-activated lactate which positively exhibits anti-tumor effect, while PAM contains some factors which positively and negatively exhibit anti-tumor effects. Both PAM and PAL induced reactive oxygen species (ROS) on glioblastomas, however, PAL induced less ROS on glioblastomas than PAM did. These results suggest that PAM and PAL exhibit anti-tumor effects on glioblastoma through different mechanisms. We are further investigating the similarities and differences of affects on survival and proliferation signaling network between PAM-treated glioblastomas and PAL-treated glioblastomas. We will present our latest knowledge of the similarities and differences between PAM- and PAL-treated glioblastoma cells.
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