Abstract
We investigated the putative common nature of the rat atypical β-adrenoceptors mediating white adipocyte lipolysis and proximal colon motility inhibition, using the non-selective antagonist alphenolol and agonist isoprenaline and the selective agonists SR 58611A and BRL 37344. Results in either isolated intestinal and fat tissues were consistent with: isoprenaline acting through both typical ( β 1, β 2) and atypical β-adrenoceptors; SR 58611A and BRL 37344 acting solely through the latter. The identical pA 2 values obtained with alprenolol, irrespective of the tissue and the selective agonist (SR 58611A or BRL 37344) used, support the high functional homology of the atypical β-adrenoceptors in rat colon and adipocytes.
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