Abstract
Historically, to generate Simian Retrovirus (SRV) positive control materials, we performed invivo passage by inoculating uninfected rhesus macaques with whole blood from an SRV-1 infected (antibody and PCR positive) macaque. However, recent attempts using this approach have failed. This study reports observations and explores why it has become more difficult to transmit SRV via invivo passage.
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