Abstract
Background Integrase defective lentiviral vectors (IDLV) represent a promising delivery system for immunization purposes. Human dendritic cells (DC) are the main cell types mediating the immune response and are readily transduced by IDLV, allowing effective triggering of in vitro expansion of antigen-specific primed CD8+ T cells. However, DC transduction efficiency is hindered by the presence of SAMHD1 restriction factor, which inhibits viral DNA synthesis.
Highlights
Integrase defective lentiviral vectors (IDLV) represent a promising delivery system for immunization purposes
These results have important implications for the development of vaccine strategies based on the use of IDLV as a novel, safe and efficient delivery system
Monocytes from HLAA*0201 and M1-positive selected donors were differentiated into dendritic cells (DC) and transduced with IDLV-M1/Vpx and control IDLV/M1 or left untreated
Summary
Integrase defective lentiviral vectors (IDLV) represent a promising delivery system for immunization purposes. DC transduction efficiency is hindered by the presence of SAMHD1 restriction factor, which inhibits viral DNA synthesis
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