Abstract
Simian foamy virus type 1 (SFV-1) is a member of a distinct subfamily of retroviruses that possess a complex genome organization as well as complex means of regulating gene expression. This virus encodes a transcriptional transactivator ( taf) that dramatically increases gene expression directed by the viral long terminal repeat. In this report, the identification of a second promoter which is significantly transactivated by SFV-1 Taf is described. The second promoter is located at the 3′ end of SFV-1 env gene downstream from position 8158 (1 represents the first nucleotide sequence of the vital genome). Deletion analysis indicated that there are at least two targets for Taf in the internal promoter. A time-course analysis of SFV-1 gene expression showed that the messages for the regulatory genes were generated prior to the transcription of the structural proteins. Therefore, SFV-1 replication may be regulated by mechanisms that involve a temporal pattern of gene expression. The potential role of the internal promoter in SFV-1 gene expression and replication is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
