Abstract
Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the cancer therapeutic effect. In this study, we investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells. AgNPs were synthesized in the sodium citrate system and the mean size were 26 nm in diameter. The AgNP particles showed dose-dependent cytotoxicity on U251 cells. They also showed the ability to enhance the drug-sensitivity of TMZ on U251 cells. Our results revealed that AgNPs could have a potential application in enhancing chemotherapy for glioma.
Highlights
Glioblastoma multiforme (GBM), one of the most common malignant tumors in the central nervous system (CNS), remains a lethal disease with poor prognosis
We investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells
It was know that AgNPs can induce dose-dependent cytotoxicities that include DNA damage and oxidative stress that can result in cell death
Summary
Glioblastoma multiforme (GBM), one of the most common malignant tumors in the central nervous system (CNS), remains a lethal disease with poor prognosis. The treatment of GBM is multimodality in which surgical resection, radiotherapy and chemotherapy play important roles [1, 2]. Chemotherapy remains the gold standard for patients who can not tolerate surgical procedure or relapse after surgery. Most glioma cancer eventually develops multidrug resistance (MDR) to current chemotherapeutic drugs that limits the effectiveness of treatment results [3, 4]. Scientists were able to synthesize nanoscale, biodegradable and biocompatible drug delivery systems with the advanced nanotechnology. Such accomplishment has made it possible to deliver anticancer drugs using nanoparticles as delivery vehicles [5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
