Silver nanoparticles coated medical fiber synthesized by surface engineering with bio-inspired mussel powered polydopamine: An investigated antimicrobial potential with bacterial membrane leakage reaction mechanism

Abstract

Nature frequently provides narrative biological motivation. This study reports on oxygen-induced auto-polymerization of dopamine on the surface of medical cotton fibers to develop super-hydrophobic surfaces. The versatile reactivity of polydopamine (PDA) surfactant was adopted to deposit silver nanoparticles (Ag NPs) on the surface of medical cotton. SEM micrographs demonstrated the uniform deposition of Ag NPs. The antimicrobial reactivity confirmed the potential of Ag-loaded PDA-cotton fiber to hinder the growth of some tested pathogenic microbes. Silver-loaded PDA-cotton fibers showed the most promising zone of inhibition (ZOI) against (33.5 mm), Candida tropicalis (30.2 mm), and Aspergillus niger (30.2 mm). In growth curve assay, after addition of silver-loaded PDA-cotton fibers, the O.D. were lower (0.365 nm), showing the repression impact on S. aureus. It was observed that the quantity of cellular protein discharged from S. aureus is directly proportional to the concentration of silver-loaded PDA-cotton fibers and found to be 159.68 μg/ml after the treatment with silver-loaded PDA-cotton fibers (2 cm × 2 cm), which proves the antibacterial characteristics of the synthesied silver-loaded PDA-cotton fibers. The obtained antimicrobial results gives solution in treating pathogenic microbes and the application of silver-loaded PDA-cotton fibers as wound dressing in biomedical and pharmaceutical fields.