Abstract
Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good handling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications.
Highlights
Nanofibers have received much attention in biomedical applications lately
The goal of this paper was to design nanofibrous wound dressings from bio-based polymers (i.e., PHAs) in order to contribute to reducing environmental pollution and to provide antimicrobial features to the PHA membranes using AgNPs
Dulbecco’s Modified Essential Medium (DMEM), L-glutamine, MgCL2, penicillin, streptomycin and fetal calf serum were bought from Invitrogen (Carlsbad, CA, USA)
Summary
Nanofibers have received much attention in biomedical applications lately. These materials have a high surface area, porosity, versatility in material choice and morphological similarities to the naturally occurring extracellular matrix, which enhances cell attachment and proliferation, transport of nutrients, gas exchange and waste excretion. The unique properties of nanofibers have attracted particular attention for wound healing applications. Contemporary wound dressings should accelerate healing with a pleasing aesthetic result [2,3]. For this purpose, they should be hemostatic, absorb exudates, manage moisture balance and thermal insulation, protect against infections and be low cost. Multifunctional dressings can be designed by the incorporation of multiple therapeutic compounds
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