Abstract
Bacterial resistance is an emerging public health issue that is disseminated worldwide. Silver nanocomposite can be an alternative strategy to avoid Gram-positive and Gram-negative bacteria growth, including multidrug-resistant strains. In the present study a silver nanocomposite was synthesized, using a new green chemistry process, by the addition of silver nitrate (1.10−3 mol·L−1) into a fermentative medium of Xanthomonas spp. to produce a xanthan gum polymer. Transmission electron microscopy (TEM) was used to evaluate the shape and size of the silver nanoparticles obtained. The silver ions in the nanocomposite were quantified by flame atomic absorption spectrometry (FAAS). The antibacterial activity of the nanomaterial against Escherichia coli (ATCC 22652), Enterococcus faecalis (ATCC 29282), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) was carried out using 500 mg of silver nanocomposite. Pseudomonas aeruginosa and Acinetobacter baumannii multidrug-resistant strains, isolated from hospitalized patients were also included in the study. The biosynthesized silver nanocomposite showed spherical nanoparticles with sizes smaller than 10 nm; 1 g of nanocomposite contained 49.24 µg of silver. Multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii, and the other Gram-positive and Gram-negative bacteria tested, were sensitive to the silver nanocomposite (10–12.9 mm of inhibition zone). The biosynthesized silver nanocomposite seems to be a promising antibacterial agent for different applications, namely biomedical devices or topical wound coatings.
Highlights
Bacterial infections affect millions of people around the world, being an important cause of morbidity and mortality and having a relevant impact on the healthcare economy [1,2]
Recent studies have shown that bacterial resistance to antibiotics spreads more quickly than the development of antimicrobial agents for their combat [4]
The biosynthesis by Xanthomonas spp. of the silver nanocomposite was obtained by a one-step process, by the addition of silver nitrate into the fermentative medium
Summary
Bacterial infections affect millions of people around the world, being an important cause of morbidity and mortality and having a relevant impact on the healthcare economy [1,2]. The treatment of these infections has become a public health concern due to bacterial resistance to antibiotics [3,4]. The interest in the synthesis of new products with antimicrobial potential is continuously increasing [6] This is the case of silver, a metal with a described antibacterial activity and significant efficacy against Gram-negative and
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