Silver(I) complexes based on novel tripodal thioglycosides: synthesis, structure and antimicrobial activity

Abstract

The reaction of tris(2-bromoethyl)amine hydrobromide with sugar thiols or thioacetates leads to the formation of novel carbohydrate substituted tripodal NS 3 ligands. Complexation with silver(I) ions gives stable complexes. NMR, X-ray, MS and EXAFS studies indicate their mononuclear C 3-symmetric structure. The highly water soluble complexes formed from the unprotected ligands show a wide spectrum of effective antimicrobial activities and their use lowers the cytotoxic and antiproliferative activities compared to the free silver salts.