Abstract
Silver(I), gold(I), and palladium(II) salts have moderate Lewis acidity and have been exploited as catalysts in organic reactions in recent years. Among these salts, Pd(II) compounds are the most well-known reagents for catalyzing a variety of carbon–carbon bond-forming reactions such as allylic alkylations [1]. Ag(I) salts are also popular reagents for promoting transformations, including glycosylation, cycloadditions, and rearrangements, which make use of their halophilicity or thiophilicity [2]. There are, however, few examples of organic reactions employing Au(I) or Au(III) compounds as Lewis acid catalysts. This chapter focuses on aldol reactions catalyzed by silver(I), gold(I), or palladium(II) Lewis acids. The Mukaiyama aldol reaction of silyl enol ethers or ketene silyl acetals and related reactions using silver(I) and palladium(II) compounds are reviewed in Section 1.2. The next section covers the diastereoand enantioselective aldol-type reactions of activated isocyanides with aldehydes.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
